CD46(169-1-E4.3) , Biotin conjugate , 0.1mg / mL

Recognizes a protein of 52 kDa-58 kDa , identified as CD46 (also known as membrane cofactor protein , MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts , moderately on lymphocytes and endothelium , and weakly on interstitial tissues and muscle cells , but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor , an adherence factor for group A Streptococcus pyogenes , and a cellular pilus receptor for pathogenic Neisseria.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.