Ku-Holo (p70;83)(KU729) , Biotin conjugate , 0.1mg / mL

Recognizes a dimer of two proteins of 70 kDa and ~80 kDa , identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer , which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling , proliferation , DNA repair , replication , transcriptional activation , and apoptosis._x000D__x000D_Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors._x000D_