gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker)(HMB45 + PMEL/783) , Biotin conjugate , 0.1mg / mL

By immunohistochemistry , this antibody specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi , normal adult melanocytes , and non-melanocytic cells are negative. It does not stain tumor cells of epithelial , lymphoid , glial , or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas , large cell lymphomas , and sarcomas using H E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This MAb stains fetal and neonatal melanocytes , junctional and blue nevus cells , and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa).