MerTK (Innate Immune Checkpoint)(MERTK/3022) , Biotin conjugate , 0.1mg / mL

MerTK , also called c-Mer , is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain , two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation , platelet aggregation , clot stability and the efficient removal of apoptotic cells. Specifically , MerTK acts as a signaling molecule , triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated , the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result , leading to degeneration of retinal photoreceptor cells. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.