AIF1 / Iba1 (Microglia Marker)(AIF1/2493) , CF647 conjugate , 0.1mg / mL

Allograft Inflammatory Factor 1 (also known as AIF1 or IBA1) is a cytoplasmic , calcium-binding protein that is thought to play a role in macrophage activation and function. AIF1 , containing two EF domains , is induced by cytokines and Interferons. In an unstimulated state , AIF1 colocalizes with actin , and upon stimulation , translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding AIF1 resides in the tumor necrosis factor (TNF) cluster of genes , located in the region represented by the human major histocompatibility complex (MHC). Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.