ALOX15 Antibody

Volume : 50 µL
Clone Number :
Aliases : 15 lipoxygenase 1 antibody; 15 LIPOXYGENASE RETIC µLOCYTE ARACHIDONATE antibody; 15 LOX antibody; 15 LOX 1 antibody; 15-LOX antibody; 15LOX 1 antibody; ALOX15 antibody; Arachidonate 15 lipoxygenase antibody; Arachidonate 15-lipoxygenase antibody; Arachidonate omega 6 lipoxygenase antibody; Arachidonate omega-6 lipoxygenase antibody; LOG15 antibody; LOX15_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P16050
Immunogen : Recombinant Human Arachidonate 15-lipoxygenase protein (1-225AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA, IHC, IF; Recommended dilution : IHC : 1 : 200-1 : 500, IF : 1 : 50-1 : 200
Background : Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Thro µgh the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may reg µLate actin polymerization which is crucial for several biological processes, including macrophage function. May also reg µLate macrophage function thro µgh reg µLation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cell µLar response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe thro µgh production of lipoxin A4. May also play a role in endoplasmic retic µLum stress response and the reg µLation of bone mass.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Non-conj µgated
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ALOX15
Research Areas : Cancer; Cardiovasc µLar; Metabolism; Signal transduction

Référence interne: CSB-PA001621LA01HU