AMACR/p504S antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-reg µLated at the transcript and protein level in hormone-refractory metastatic PCa, s µggesting a hormone-dependent expression of AMACR(PMID : 12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID : 21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
Immunogen : alpha-methylacyl-CoA racemase
Aliases : 2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE
Observed MW : 42 kDa
Uniprot ID : Q9UHK6
Reactivity : Human, rat
Application : ELISA, IHC, WB
Recommended dilution : WB : 1 : 500-1 : 5000; IHC : 1 : 20-1 : 200
Gene ID :
Research Area : Stem Cells, Immunology, Metabolism, Cancer

Référence interne: FNab00355